Dracula's brides must reunite to stop a threats from their past, their sister Mina. With the help of a powerful cartel leader and an army of drug lords under her command, Mina throws Los Angeles into utter chaos, raging for blood.

Four upper-class high school students who live carefree between drugs, games and love until one of the girls, Eli, is brutally killed. Sixteen years later, the memory of the crime torments Alain, another member of the group.

After a massive shootout, a mysterious stranger (Van Damme) arrives at a local hospital on the brink of death. Then, a foreign gang brazenly comes to the hospital to hunt him down. His nurse, the sole surviving witness to the follow-up shootout, must face an FBI interrogation that unlocks a plot of international intrigue and revenge. With enough twists and turns, KILL'EM ALL will keep you guessing until the final bullet is fired.